The China Salt Substitute Study was an important early trial examining potassium-enriched salt, blood pressure and acceptability in China before the later SSaSS mega-trial.
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Principal Investigators
ClinicalTrials.gov lists Bruce Neal, Yangfeng Wu, Rachel Huxley and John Prescott among the principal investigators.
The George Institute sponsored the trial with collaborators in China and Australia.
Taste and Saltiness
The registry includes sensory outcomes such as food taste and preferred level of saltiness in addition to cardiovascular measures.
This shows that acceptability was already being studied in the early development of salt-substitution interventions.
Research Pathway to SSaSS
Early Chinese studies helped establish the foundation for the much larger SSaSS program involving 600 villages and about 21,000 participants.
The research pathway expanded from short-term biomarkers and acceptability to hard clinical outcomes.
Sources
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