The Salt Substitute and Stroke Study is one of the largest randomized trials directly testing whether changing the composition of household salt affects clinical outcomes.
More information on this topic is available in the Scientific Salt Research section.
Study Design
Villages were cluster-randomized to salt substitute or regular salt.
Participants had a prior stroke or were aged 60 years or older and had hypertension.
Main Outcomes
The NEJM paper reported a lower rate of fatal or nonfatal stroke in the salt-substitute group than in the regular-salt group.
Major cardiovascular events and all-cause death were also reported at lower rates.
Safety Outcome
Hyperkalemia was monitored as a safety outcome and the trial reported no apparent increase in serious adverse effects.
The findings apply to the specific population, formulation and trial conditions studied.
Sources
- New England Journal of Medicine – Effect of Salt Substitution on Cardiovascular Events and Death
- New England Journal of Medicine – SSaSS Research Summary
Rock Salt Brands and Supply Channels
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