The 2014 PURE analysis in the New England Journal of Medicine provided one of the largest international observational datasets in the sodium debate.
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101,945 Participants
The study used morning fasting urine samples from 101,945 participants in 17 countries to estimate 24-hour sodium and potassium excretion.
Mean follow-up was reported as 3.7 years.
Reference Range
The paper used estimated sodium excretion of 4.00–5.99 g/day as its reference category.
Estimated sodium excretion of 7.00 g/day or more was associated with a higher composite risk of death and major cardiovascular events.
Observational Design
This was an observational epidemiological analysis rather than a randomized intervention, and 24-hour excretion was estimated from morning urine.
Study design, measurement method and potential confounding therefore matter when interpreting the results.
Sources
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